Centre for Clinical Research (CCR)
The Centre for clinical research (CCR) was established in 1985 as a clinical trials unit to support development of drugs and vaccines aimed at tackling priority disease conditions in the country. It has grown over time and established linkages with key institutions and partners notably the United States Medical Research Unit (USAMRU) , Drugs for Neglected Diseases Initiative (DNDi), where KEMRI is a founding member, the University of Washington, Foundation for Innovative New Diagnostics (FIND) , University of Texas Medical Branch (UTMB).
The centre scientists have undertaken numerous clinical trials initially these were for the treatment of leishmaniasis (kala azar) in children. During this inception years, CCR was a must visit site for the university of Nairobi Medical students to understand the value of research in drug development and the appropriate treatment of patients. In the last two decades the researchers in the centre have made milestones in therapeutics of HIV and Malaria and tested various drugs for prevention and treatment of these disease. The Malaria Vaccine, which is now on roll out in the country is one such product. On the HIV AIDS management front, many clinical trials have been undertaken in the areas of Pre- Exposure Prophylaxis (PREP), Prevention of Mother to Child Transmission (PMCT), adolescent HIV and adult HIV treatment. The basic sciences have developed diagnostic tools and tested devices included multiplex systems for an array of infections.
With the increasing burden of Non-Communicable Diseases (NCDs) the scientists have started undertaking studies in sickle cell disease, Cervical Cancer Vaccine, among others. Disease Surveillance is also some of the area we are strong in, in particular Malaria Drug Resistance, Vector Biology and Cancer.
The research team is composed of experienced scientists with various expertise and competencies including clinical trialists, clinicians, pharmacists, specialists, nurses, technologists, health records and information and the adjunct support personnel.
Over time distinct collaborative platforms have been established at the different stations outside the Nairobi one, notably in Kericho, Thika, Kisumu and Kombewa among others all working closely with the respective county governments and partners.
The National Cancer Registry is also housed here at the Nairobi Station and functions to support the Ministry of Health in cancer incidence, mortality and trends reporting and also capacity building for cancer registration.
All this research work is supported by accredited basic clinical laboratories with advanced diagnostic platforms and pharmacies.
In Nairobi an endoscopy suite and a medical imaging department is also being revamped for more research.
The centre supports the KEMRI-Nairobi Medical Centre, which is an outpatient facility that attends to staff and members of the public. Through this facility the highly specialized diagnostic test within KEMRI may be accessed.
FUNCTIONS OF THE CCR;
- Undertake research in Communicable and Non-Communicable Diseases
- Provide a platform for clinical trials (drug safety and efficacy) in Neglected, Communicable and Non-Communicable Diseases
- Provide a conducive environment for patient/participant monitoring, support and safety
- Test new therapies, tools and vaccines for new therapies
- Validate drug therapies or compounds for efficacy and safety
- Collaborate with others to undertake implementation research
- Link and partner with pharmaceutical industry and others to test drug molecules in our market
- Support MOH disease programs in conducting national surveys
- Monitor disease trends and undertake surveys in specific disease areas
- Assist the MOH in reviewing therapies and strategies for disease control
- Keep a register and monitor disease trends and incidences
- Provide clinical services to outpatients and projects
- Undertake diagnostic and therapeutic services to support patient care
- Initiate and maintain collaboration and partnerships
In the division the mandate is to undertake research in Neglected Tropical Diseases (NTD’s) with special emphasis of Visceral Leishmaniasis (VL) which is the most serious form of the disease.
- Laboratory Testing Services
- Microscopy onsite Training for Vaccine/Drug Trials
- SCREENING FOR PTB PRE ARV TREATMENT.
Dr. Veronica Kemunto Manduku
Deputy Director Centre For Clinical Research
Dr. Veronica Manduku is the Deputy Director, Centre for Clinical Research and has a background in diagnostic imaging. She holds a Bachelor’s degree in Medicine and Surgery from Pune University, India (1996) and a Masters in Medicine in Diagnostic Imaging from the University of Nairobi (2003). As a director, she coordinates a robust research team with expertise in clinical trials, epidemiology and basic sciences within several research stations including the Nairobi, Kisumu, Kericho and Thika counties. The team typically undertakes research in key infectious diseases like HIV, Malaria, Leishmaniasis, Sickle cell disease and a good number in Non-Communicable Diseases (NCDs) like Mental and dental health, cancer, child and adolescent health, reproductive health among others.
Her objectives are in improving quality of cancer care in Kenya through research and enhanced understanding of cancer and other major NCDs.
|She is also keen in chest imaging with her past work being in supporting the Malaria vaccine trial and the Pneumonia Etiology survey in radiation safety, standardization of reading and review of images. In 2015, she was the lead imaging expert in the first ever Kenya National Tuberculosis Survey.
She supports MOH through various technical working groups in cancer control program.
She is currently the chair of the Kenya Society for Ultrasound in Medicine and Biology (KESUMB). A member of African Society of Radiologists (ASR).
In the past she has served as a board member in the Kenya Radiation Protection Board (KRPB) and chair, Kenya Association of Radiologists (KAR).
- Cancer prevention, screening and diagnosis
- Chest imaging and Tuberculosis.
- Implementation science in NCDS
- P.O. BOX 20778- 00202
1) Kenyan PI –: Inactivation of the PRH/HHEX tumor suppressor and its effects on inflammatory signaling in prostate cancer. (Joint NRF/MRC funded proposal: 2019)
2) Co-Investigator: How to link industrial and social innovation for inclusive development: lessons from tackling the “hard case” of cancer care in Africa (ESRC Funded: November 2018)
3) Co- Investigator: Systematic review of Oncology in Kenya NRF funded Ongoing study. 2018
4) Principle investigator: Pattern and factors associated with use of psychoactive substance among female commercial sex workers in Kibra, Nairobi County. IRG/ GOK funding 2017
5) CO- Investigator: Spatial distribution and epidemiology of cancers in Kenya: mapping the disease burden. IRG/ GOK funding 2017
6) Co- investigator: Assessing health factors and experiences associated with Khat handling and chewing in selected areas of Kenya. GOK Funded 2016
Kenya Medical Research Institute
Centre for Clinical Research Laboratories
P.O Box 20778-00202 Nairobi. Tel: +254 020 2726781, +254 020 2722541, +254 020 2713349, 0722205901, 0733400003.